THE EFFECT OF THE ANTINEOPLASTIC DRUG UKRAIN ON THE ELECTROKINETIC POTENTIAL OF MALIGNANT AND NORMAL CELLS
Romodanov Institute of Neurosurgery, Academy of Medical Sciences, Kiev, Ukraine.
Address for correspondence: I.N. Todor, Romodanov Institute of Neurosurgery, Academy of Medical Sciences, Vul. Manuilskoho 32, 04050, Kiev, Ukraine.
Summary: The effect of Ukrain, a thiophosphamide derivative of alkaloids of Chelidonium majus L, on the electrokinetic potential of normal and tumor cells was studied. Initially the electrophoretic mobility of cells was determined using a purpose-built device. Subsequently their electrokinetic potential was calculated. Ukrain significantly decreased electrokinetic potential. Thiophosphamide and alkaloids of greater celandine also reduced electrokinetic potential, but only at much higher concentrations than Ukrain. In addition, the toxicity of Ukrain was lower than that of both thiophosphamide and greater celandine alkaloids.