Ukrain (NSC-631570) inhibits angiogenic differentiation of human endothelial cells in vitro
Y. KOSHELNICK, E. MOSKVINA*, B.R. BINDER and J.W. NOWICKY**
Department of Vascular Biology and Thrombosis Research
* Institute of Biochemistry and Molecular Cell Biology
Vienna University, Vienna (A)
** Ukrainian Anti-Cancer Institute, Vienna (A)
Ukrain, a semi-synthetic drug derived from alkaloids of Chelidonium majus L. conjugated to thiophosphoric acid, has been reported to have therapeutic efficacy in treatment of patients with advanced primary and metastatic malignancies. This drug has unique properties such as direct stimulation of cytolytic activity of immune effector cells and tumor-specific cytotoxic activity. In this study we demonstrated that Ukrain also acts as a potent inhibitor of m vitro angiogenesis.