ANTIMETASTATIC EFFECT OF UKRAIN AND ITS INFLUENCE ON THE OXYGEN AND ENERGY METABOLISM OF MICE WITH MELANOMA B-16

S.V. Zemskov1, Ya.M. Susak1, I.N. Todor2*, L.T. Khasanova2, V.S. Mosienko2

1A.A. Bogomoletz National Medical University, Kyiv 252012, Ukraine
2R.E.Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv 252022, Ukraine

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The influence of intravenous injections of Ukrain (1mg/kg) on the oxygen tension (02) in muscle, the oxygen saturation rate and oxygen utilization rate as well as on the respiration and oxidative phosphorylation indices of the liver mitochondria in mice with melanoma B-16 was studied by polarographic method. Ukrain was shown to improve the oxygen delivery to the muscular tissue and to decrease a destructive effect of the malignant process on liver bioenergetics. The respiration rate of mitochondria during phosphorylation of exogenous ADP and the respiratory control coefficient were higher in the treated mice as compared to the untreated tumor-bearing animals. The drug significantly inhibited the growth of the primary tumor and its metastasis in lungs.

Key Words: Ukrain, oxygen tension, mitochondria respiration, metastasis.