Brzosko W.J., Uglianica K.*, Fomin K.*, Nowicky J.W.**

Roch Brzosko Memorial Center for Natural Medicine, Warsaw, Poland
Oncology Clinic of Medical Academy, Grodno, Byelorussia*
Anticancer Ukrain Institute, Vienna, Austria**

In our previous studies done on patients with ovarian and colorectal cancers it was demonstrated that Ukrain may suppress the tumor growth by a direct cytostatic effect as well as by an increase of anti-tumor immunity, mediated by cytotoxic Τ lymphocytes and NK cells. In the present study Ukrain anti-tumor potency on the breast cancer will be demonstrated.

The studies were carried out in 10 women in whom stage IIB of breast cancer was diagnosed. Prior to radical mastectomy the patients were treated with Ukrain injected i.v. every second day for 20 days. After Ukrain treatment the most characteristic was the tumor hardness and its sharp contrast with the surrounding tissue. By mammography the tumors were found more contrasting as before treatment with the drug. By histology the tumors were found to be encapsulated with connective tissue heavily infiltrated by mononuclears composed mostly of lymphocytes and plasma cells. Inside the tumors were found scattered necrotic foci separated by neoplastic tissue as well as by bundles of connective tissue infiltrated with cells similar to those found in the fibrotic capsule. In some places lymphocytic infiltrates formed lymph nodules.

The present studies support our previous observations on the mode of action of Ukrain and suggest that the drug by changing the antigenic expression of neoplastic cells, makes them recognizable by the immune system.